Leukodystrophy, Metachromatic - 25 Studies Found
Active, not recruiting |
: The Natural History of Metachromatic Leukodystrophy : Metachromatic Leukodystrophy : 2008-03-11 |
Completed |
: Multicenter Study of HGT-1110 Administered Intrathecally in Children With Metachromatic Leukodystrophy (MLD) : Metachromatic Leukodystrophy (MLD) : 2011-12-14 : Biological: Recombinant human arylsulfatase A 6 patients treated with HGT-1110 EOW by IT injection |
Completed |
: Effect of Warfarin in the Treatment of Metachromatic Leukodystrophy : Metachromatic Leukodystrophy : 2008-05-21 : Drug: Warfarin Oral administration (QD), variable dosage: patients will undergo blood test for PT/INR at |
Completed |
: Long-term Metazym Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD) : Late Infantile Metachromatic Leukodystrophy : 2008-02-29 : Biological: Recombinant human Arylsulfatase A (rhASA) intravenous infusion, every other week for 26 week |
Recruiting |
: Intracerebral Gene Therapy for Children With Early Onset Forms of Metachromatic Leukodystrophy : Metachromatic Leukodystrophy : 2013-01-28 : Genetic: intracerebral administration of AAVrh.10cuARSA |
Completed |
: Imaging Study of the White Matter Lesions in Children With Metachromatic Leucodystrophy : Late Infantile Metachromatic Leukodystrophy : 2011-03-09 : Other: High-field MRI (3 Teslas) |
Enrolling by invitation |
: Open-Label Extension Study Evaluating Safety and Efficacy of HGT-1110 in Patients With Metachromatic Leukodystrophy : Metachromatic Leukodystrophy (MLD) : 2013-06-20 :
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Completed |
: Metazym for the Treatment of Patients With Late Infantile Metachromatic Leukodystrophy (MLD) : Metachromatic Leukodystrophy (MLD) : 2007-01-04 : Drug: rhASA intravenous infusion 25 U/kg,50 U/kg, 100U/kg or 200 U/kg every other week for 26 weeks |
Completed |
: Efficacy METAZYM for the Treatment Metachromatic Leukodystrophy Treated With Hematopoietic Stem Cell Transplantation : Metachromatic Leukodystrophy : 2011-02-23 : Drug: rhARSA intravenous infusion 100U/kg every other week for 18 months |
Terminated |
: Open-Label Extension Study of Recombinant Human Arylsulfatase A (HGT-1111) in Late Infantile MLD : Late Infantile Metachromatic Leukodystrophy : 2008-05-19 : Drug: HGT-1111 Patients currently dosed with 100 U/kg or 200 U/kg will continue this treatment. Patients |